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Heterotopic Mucosal Engrafting Procedure for Direct Drug Delivery to the Brain in Mice

Delivery of therapeutics into the brain is impeded by the presence of the blood-brain barrier (BBB) which restricts the passage of polar and high molecular weight compounds from the bloodstream and into brain tissue. Some direct delivery success in humans has been achieved via implantation of transc...

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Detalhes bibliográficos
Main Authors: Kohman, Richie E., Han, Xue, Bleier, Benjamin S.
Formato: Artigo
Idioma:Inglês
Publicado em: MyJove Corporation 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217501/
https://ncbi.nlm.nih.gov/pubmed/25077554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/51452
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