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Heterotopic Mucosal Engrafting Procedure for Direct Drug Delivery to the Brain in Mice

Delivery of therapeutics into the brain is impeded by the presence of the blood-brain barrier (BBB) which restricts the passage of polar and high molecular weight compounds from the bloodstream and into brain tissue. Some direct delivery success in humans has been achieved via implantation of transc...

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Autors principals: Kohman, Richie E., Han, Xue, Bleier, Benjamin S.
Format: Artigo
Idioma:Inglês
Publicat: MyJove Corporation 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217501/
https://ncbi.nlm.nih.gov/pubmed/25077554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/51452
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