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A necessary role of DNMT3A in endurance exercise by suppressing ALDH1L1‐mediated oxidative stress

Exercise can alter the skeletal muscle DNA methylome, yet little is known about the role of the DNA methylation machinery in exercise capacity. Here, we show that DNMT3A expression in oxidative red muscle increases greatly following a bout of endurance exercise. Muscle‐specific Dnmt3a knockout mice...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Damal Villivalam, Sneha, Ebert, Scott M, Lim, Hee Woong, Kim, Jinse, You, Dongjoo, Jung, Byung Chul, Palacios, Hector H, Tcheau, Tabitha, Adams, Christopher M, Kang, Sona
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8090849/
https://ncbi.nlm.nih.gov/pubmed/33847380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020106491
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