Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development

Parental origin-specific DNA methylation regulates the monoallelic expression of the mammalian imprinted genes. The methylation marks or imprints are established in the parental germline and maintained throughout embryonic development. However, it is unclear how the methylation imprints are maintain...

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Autors principals: Hirasawa, Ryutaro, Chiba, Hatsune, Kaneda, Masahiro, Tajima, Shoji, Li, En, Jaenisch, Rudolf, Sasaki, Hiroyuki
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2008
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2428059/
https://ncbi.nlm.nih.gov/pubmed/18559477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1667008
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