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Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development

Parental origin-specific DNA methylation regulates the monoallelic expression of the mammalian imprinted genes. The methylation marks or imprints are established in the parental germline and maintained throughout embryonic development. However, it is unclear how the methylation imprints are maintain...

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Detalhes bibliográficos
Main Authors: Hirasawa, Ryutaro, Chiba, Hatsune, Kaneda, Masahiro, Tajima, Shoji, Li, En, Jaenisch, Rudolf, Sasaki, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2428059/
https://ncbi.nlm.nih.gov/pubmed/18559477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1667008
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