Sox2 Is Required Independently in Both Stem and Differentiated Cells for Pituitary Tumour Genesis in P27 Null Mice

Tumour development can depend on cell intrinsic dysfunction, but, in some cases, extrinsic factors are important drivers. Here, we have established a genetically tractable model demonstrating that the same gene is relevant both cell-autonomously and non-cell-autonomously for tumorigenesis. P27, a ce...

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Bibliographic Details
Published in:J Endocr Soc
Main Authors: Moncho-Amor, Veronica, Chakravarty, Probir, Galichet, Christophe, Lovell-Badge, Robin, Rizzoti, Karine
Format: Artigo
Language:Inglês
Published: Oxford University Press 2021
Subjects:
Genetics and Development (including Gene Regulation)
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8090700/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvab048.1043
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