Sox2 Is Required Independently in Both Stem and Differentiated Cells for Pituitary Tumour Genesis in P27 Null Mice

Tumour development can depend on cell intrinsic dysfunction, but, in some cases, extrinsic factors are important drivers. Here, we have established a genetically tractable model demonstrating that the same gene is relevant both cell-autonomously and non-cell-autonomously for tumorigenesis. P27, a ce...

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Bibliographische Detailangaben
Veröffentlicht in:J Endocr Soc
Hauptverfasser: Moncho-Amor, Veronica, Chakravarty, Probir, Galichet, Christophe, Lovell-Badge, Robin, Rizzoti, Karine
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2021
Schlagworte:
Genetics and Development (including Gene Regulation)
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8090700/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvab048.1043
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