Effects of CRN04894, a Nonpeptide Orally Bioavailable ACTH Antagonist, on Corticosterone in Rodent Models of ACTH Excess

CRN04894 is an orally administered nonpeptide that is a potent and selective antagonist for adrenocorticotropic hormone (ACTH) acting at the melanocortin 2 receptor (MC2R) and is currently under development for the treatment of diseases of ACTH excess such as Cushing’s disease, congenital adrenal hy...

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Veröffentlicht in:J Endocr Soc
Hauptverfasser: Fowler, Melissa A, Kusnetzow, Ana Karin, Han, Sangdon, Reinhart, Greg, Kim, Sun Hee, Johns, Michael, Kredel, Taylor A, Antwan, Agnes, Athanacio, Jon, Tsivkovski, Oleg, Luo, Rosa, Madan, Ajay, Zhu, Yun Fei, Betz, Stephen F, Struthers, Scott, Markison, Stacy
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2021
Schlagworte:
Adrenal
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8090401/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvab048.337
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