Effects of CRN04894, a Nonpeptide Orally Bioavailable ACTH Antagonist, on Corticosterone in Rodent Models of ACTH Excess

CRN04894 is an orally administered nonpeptide that is a potent and selective antagonist for adrenocorticotropic hormone (ACTH) acting at the melanocortin 2 receptor (MC2R) and is currently under development for the treatment of diseases of ACTH excess such as Cushing’s disease, congenital adrenal hy...

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Publicat a:J Endocr Soc
Autors principals: Fowler, Melissa A, Kusnetzow, Ana Karin, Han, Sangdon, Reinhart, Greg, Kim, Sun Hee, Johns, Michael, Kredel, Taylor A, Antwan, Agnes, Athanacio, Jon, Tsivkovski, Oleg, Luo, Rosa, Madan, Ajay, Zhu, Yun Fei, Betz, Stephen F, Struthers, Scott, Markison, Stacy
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2021
Matèries:
Adrenal
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8090401/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvab048.337
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