MON-176 Discovery and Identification of Late Stage Selective Nonpeptide ACTH Antagonists for the Treatment of Cushing’s Disease, Ectopic ACTH Secreting Tumors, and Congenital Adrenal Hyperplasia

Adrenocorticotropic hormone (ACTH) is an important modulator of steroidal hormone synthesis and secretion from the adrenal gland and its selective activity at the melanocortin type 2 receptor (MC2) dictates the synthesis and secretion of cortisol (corticosterone in rats). Excess ACTH action contribu...

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Bibliografske podrobnosti
izdano v:J Endocr Soc
Main Authors: Kusnetzow, Ana Karin, Han, Sangdon, Fowler, Melissa A, Athanacio, Jon, Reinhart, Greg, Rico, Elizabeth, Kim, Sun Hee, Johns, Michael, Kredel, Taylor A, Antwan, Agnes, Tsivkovski, Oleg, Nguyen, Julie, Staley, Christine, Tan, Hannah, Luo, Rosa, Markison, Stacy, Madan, Ajay, Zhu, Yun Fei, Struthers, Scott, Betz, Stephen F
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Adrenal
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7209750/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.690
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