MON-176 Discovery and Identification of Late Stage Selective Nonpeptide ACTH Antagonists for the Treatment of Cushing’s Disease, Ectopic ACTH Secreting Tumors, and Congenital Adrenal Hyperplasia

Adrenocorticotropic hormone (ACTH) is an important modulator of steroidal hormone synthesis and secretion from the adrenal gland and its selective activity at the melanocortin type 2 receptor (MC2) dictates the synthesis and secretion of cortisol (corticosterone in rats). Excess ACTH action contribu...

詳細記述

保存先:
書誌詳細
出版年:J Endocr Soc
主要な著者: Kusnetzow, Ana Karin, Han, Sangdon, Fowler, Melissa A, Athanacio, Jon, Reinhart, Greg, Rico, Elizabeth, Kim, Sun Hee, Johns, Michael, Kredel, Taylor A, Antwan, Agnes, Tsivkovski, Oleg, Nguyen, Julie, Staley, Christine, Tan, Hannah, Luo, Rosa, Markison, Stacy, Madan, Ajay, Zhu, Yun Fei, Struthers, Scott, Betz, Stephen F
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2020
主題:
Adrenal
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7209750/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.690
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