SAT-364 Nonpeptide Orally-Bioavailable ACTH Antagonists: Suppression of ACTH-Induced Corticosterone Secretion and Adrenal Hypertrophy in Rats

Cushing’s disease is most commonly the result of a microadenoma derived from pituitary corticotrophic cells that secretes excess adrenocorticotropic hormone (ACTH). ACTH is an important modulator of steroidal hormone synthesis and secretion from the adrenal gland and its selective activity at the me...

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Bibliographic Details
Published in:J Endocr Soc
Main Authors: Kusnetzow, Ana, Fowler, Melissa, Athanacio, Jon, Reinhart, Greg, Rico-Bautista, Elizabeth, Han, Sangdon, Kim, Sun Hee, Johns, Michael, Kredel, Taylor, Nguyen, Julie, Staley, Christine, Tan, Hannah, Luo, Rosa, Markison, Stacy, Madan, Ajay, Zhu, Yun Fei, Struthers, Scott, Betz, Stephen
Format: Artigo
Language:Inglês
Published: Endocrine Society 2019
Subjects:
Adrenal
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6552531/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2019-SAT-364
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