A Prospective Cross-Over Study of Tissue Glucocorticoid Metabolism in Patients With Adrenal Insufficiency: The Effects of Dual-Release Hydrocortisone Therapy

Background: Patients with adrenal insufficiency (AI) require life-long glucocorticoid (GC) replacement therapy. Within tissues, cortisol (F) availability is under the control of the isozymes of 11β-hydroxysteroid dehydrogenase (11β-HSD). We hypothesize that GC metabolism is altered in patients with...

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Bibliografske podrobnosti
izdano v:J Endocr Soc
Main Authors: Dineen, Rosemary Anne, Martin-Grace, Julie, Saeed Ahmed, Khalid Mohamed, Taylor, Angela Elizabeth, Shaheen, Fozia, Schiffer, Lina, Gilligan, Lorna, Frizelle, Isolda Mary, Gunness, Anjuli, Garrahy, Aoife, Hannon, Anne marie, O’Reilly, Michael William, Smith, Diarmuid, McDermott, John, Marie-Louise, Healy, Agha, Amar, Pazderska, Agnieszka, Gibney, James, Behan, Lucy-Ann, Arlt, Wiebke, Thompson, Chris John, Sherlock, Mark
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2021
Teme:
Adrenal
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8089674/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvab048.150
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