HIF1α-dependent induction of the mitochondrial chaperone TRAP1 regulates bioenergetic adaptations to hypoxia

The mitochondrial paralog of the Hsp90 chaperone family TRAP1 is often induced in tumors, but the mechanisms controlling its expression, as well as its physiological functions remain poorly understood. Here, we find that TRAP1 is highly expressed in the early stages of Zebrafish development, and its...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Laquatra, Claudio, Sanchez-Martin, Carlos, Dinarello, Alberto, Cannino, Giuseppe, Minervini, Giovanni, Moroni, Elisabetta, Schiavone, Marco, Tosatto, Silvio, Argenton, Francesco, Colombo, Giorgio, Bernardi, Paolo, Masgras, Ionica, Rasola, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8088431/
https://ncbi.nlm.nih.gov/pubmed/33934112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03716-6
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