Inhibition of succinate dehydrogenase by the mitochondrial chaperone TRAP1 has anti-oxidant and anti-apoptotic effects on tumor cells

TRAP1 is a mitochondrial chaperone highly expressed in many tumor types; it inhibits respiratory complex II, down-modulating its succinate dehydrogenase (SDH) enzymatic activity. SDH inhibition in turn leads to a pseudohypoxic state caused by succinate-dependent HIF1α stabilization and promotes neop...

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Bibliografiska uppgifter
I publikationen:Oncotarget
Huvudupphovsmän: Guzzo, Giulia, Sciacovelli, Marco, Bernardi, Paolo, Rasola, Andrea
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2014
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4323003/
https://ncbi.nlm.nih.gov/pubmed/25564869
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