The Mitochondrial Chaperone TRAP1 Promotes Neoplastic Growth by Inhibiting Succinate Dehydrogenase

We report that the mitochondrial chaperone TRAP1, which is induced in most tumor types, is required for neoplastic growth and confers transforming potential to noncancerous cells. TRAP1 binds to and inhibits succinate dehydrogenase (SDH), the complex II of the respiratory chain. The respiratory down...

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Detalhes bibliográficos
Main Authors: Sciacovelli, Marco, Guzzo, Giulia, Morello, Virginia, Frezza, Christian, Zheng, Liang, Nannini, Nazarena, Calabrese, Fiorella, Laudiero, Gabriella, Esposito, Franca, Landriscina, Matteo, Defilippi, Paola, Bernardi, Paolo, Rasola, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3677096/
https://ncbi.nlm.nih.gov/pubmed/23747254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.04.019
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