Tenofovir and adefovir down-regulate mitochondrial chaperone TRAP1 and succinate dehydrogenase subunit B to metabolically reprogram glucose metabolism and induce nephrotoxicity

Despite the therapeutic success of tenofovir (TFV) for treatment of HIV-1 infection, numerous cases of nephrotoxicity have been reported. Mitochondrial toxicity has been purported as the major target of TFV-associated renal tubulopathy but the underlying molecular mechanism remains unclear. In this...

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Publicado no:Sci Rep
Main Authors: Zhao, Xinbin, Sun, Kun, Lan, Zhou, Song, Wenxin, Cheng, Lili, Chi, Wenna, Chen, Jing, Huo, Yi, Xu, Lina, Liu, Xiaohui, Deng, Haiteng, Siegenthaler, Julie A., Chen, Ligong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5387747/
https://ncbi.nlm.nih.gov/pubmed/28397817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep46344
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