Tenofovir and adefovir down-regulate mitochondrial chaperone TRAP1 and succinate dehydrogenase subunit B to metabolically reprogram glucose metabolism and induce nephrotoxicity

Despite the therapeutic success of tenofovir (TFV) for treatment of HIV-1 infection, numerous cases of nephrotoxicity have been reported. Mitochondrial toxicity has been purported as the major target of TFV-associated renal tubulopathy but the underlying molecular mechanism remains unclear. In this...

全面介紹

Na minha lista:
書目詳細資料
發表在:Sci Rep
Main Authors: Zhao, Xinbin, Sun, Kun, Lan, Zhou, Song, Wenxin, Cheng, Lili, Chi, Wenna, Chen, Jing, Huo, Yi, Xu, Lina, Liu, Xiaohui, Deng, Haiteng, Siegenthaler, Julie A., Chen, Ligong
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2017
主題:
Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5387747/
https://ncbi.nlm.nih.gov/pubmed/28397817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep46344
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!

相似書籍