Honokiol Bis-Dichloroacetate Is a Selective Allosteric Inhibitor of the Mitochondrial Chaperone TRAP1

Aims: TNF receptor-associated protein 1 (TRAP1), the mitochondrial paralog of the heat shock protein 90 (Hsp90) family of molecular chaperones, is required for neoplastic growth in several tumor cell models, where it inhibits succinate dehydrogenase (SDH) activity, thus favoring bioenergetic rewirin...

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Detalhes bibliográficos
Publicado no:Antioxid Redox Signal
Main Authors: Sanchez-Martin, Carlos, Menon, Daniela, Moroni, Elisabetta, Ferraro, Mariarosaria, Masgras, Ionica, Elsey, Justin, Arbiser, Jack L., Colombo, Giorgio, Rasola, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc., publishers 2021
Assuntos:
Forum Original Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020504/
https://ncbi.nlm.nih.gov/pubmed/32438819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2019.7972
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