Honokiol Bis-Dichloroacetate Is a Selective Allosteric Inhibitor of the Mitochondrial Chaperone TRAP1

Aims: TNF receptor-associated protein 1 (TRAP1), the mitochondrial paralog of the heat shock protein 90 (Hsp90) family of molecular chaperones, is required for neoplastic growth in several tumor cell models, where it inhibits succinate dehydrogenase (SDH) activity, thus favoring bioenergetic rewirin...

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Vydáno v:Antioxid Redox Signal
Hlavní autoři: Sanchez-Martin, Carlos, Menon, Daniela, Moroni, Elisabetta, Ferraro, Mariarosaria, Masgras, Ionica, Elsey, Justin, Arbiser, Jack L., Colombo, Giorgio, Rasola, Andrea
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc., publishers 2021
Témata:
Forum Original Research Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020504/
https://ncbi.nlm.nih.gov/pubmed/32438819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2019.7972
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