Honokiol Bis-Dichloroacetate Is a Selective Allosteric Inhibitor of the Mitochondrial Chaperone TRAP1

Aims: TNF receptor-associated protein 1 (TRAP1), the mitochondrial paralog of the heat shock protein 90 (Hsp90) family of molecular chaperones, is required for neoplastic growth in several tumor cell models, where it inhibits succinate dehydrogenase (SDH) activity, thus favoring bioenergetic rewirin...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Antioxid Redox Signal
Prif Awduron: Sanchez-Martin, Carlos, Menon, Daniela, Moroni, Elisabetta, Ferraro, Mariarosaria, Masgras, Ionica, Elsey, Justin, Arbiser, Jack L., Colombo, Giorgio, Rasola, Andrea
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Mary Ann Liebert, Inc., publishers 2021
Pynciau:
Forum Original Research Communication
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020504/
https://ncbi.nlm.nih.gov/pubmed/32438819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2019.7972
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg