HIF1α-dependent induction of the mitochondrial chaperone TRAP1 regulates bioenergetic adaptations to hypoxia

The mitochondrial paralog of the Hsp90 chaperone family TRAP1 is often induced in tumors, but the mechanisms controlling its expression, as well as its physiological functions remain poorly understood. Here, we find that TRAP1 is highly expressed in the early stages of Zebrafish development, and its...

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Pubblicato in:Cell Death Dis
Autori principali: Laquatra, Claudio, Sanchez-Martin, Carlos, Dinarello, Alberto, Cannino, Giuseppe, Minervini, Giovanni, Moroni, Elisabetta, Schiavone, Marco, Tosatto, Silvio, Argenton, Francesco, Colombo, Giorgio, Bernardi, Paolo, Masgras, Ionica, Rasola, Andrea
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8088431/
https://ncbi.nlm.nih.gov/pubmed/33934112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03716-6
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