TP53 germline mutations in the context of families with hereditary breast and ovarian cancer: a clinical challenge

PURPOSE: TP53germline (g) mutations, associated with the Li-Fraumeni syndrome (LFS), have rarely been reported in the context of hereditary breast and ovarian cancer (HBOC). The prevalence and cancer risks in this target group are unknown and counseling remains challenging. Notably an extensive high...

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Enregistré dans:
Détails bibliographiques
Publié dans:Arch Gynecol Obstet
Auteurs principaux: Grill, Sabine, Ramser, Juliane, Hellebrand, Heide, Pfarr, Nicole, Boxberg, Melanie, Brambs, Christine, Ditsch, Nina, Meindl, Alfons, Groß, Eva, Meitinger, Thomas, Kiechle, Marion, Quante, Anne S.
Format: Artigo
Langue:Inglês
Publié: Springer Berlin Heidelberg 2020
Sujets:
Gynecologic Oncology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8087555/
https://ncbi.nlm.nih.gov/pubmed/33245408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00404-020-05883-x
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