TP53 germline mutations in the context of families with hereditary breast and ovarian cancer: a clinical challenge

PURPOSE: TP53germline (g) mutations, associated with the Li-Fraumeni syndrome (LFS), have rarely been reported in the context of hereditary breast and ovarian cancer (HBOC). The prevalence and cancer risks in this target group are unknown and counseling remains challenging. Notably an extensive high...

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Dettagli Bibliografici
Pubblicato in:Arch Gynecol Obstet
Autori principali: Grill, Sabine, Ramser, Juliane, Hellebrand, Heide, Pfarr, Nicole, Boxberg, Melanie, Brambs, Christine, Ditsch, Nina, Meindl, Alfons, Groß, Eva, Meitinger, Thomas, Kiechle, Marion, Quante, Anne S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Berlin Heidelberg 2020
Soggetti:
Gynecologic Oncology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8087555/
https://ncbi.nlm.nih.gov/pubmed/33245408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00404-020-05883-x
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