TP53 germline mutations in the context of families with hereditary breast and ovarian cancer: a clinical challenge

PURPOSE: TP53germline (g) mutations, associated with the Li-Fraumeni syndrome (LFS), have rarely been reported in the context of hereditary breast and ovarian cancer (HBOC). The prevalence and cancer risks in this target group are unknown and counseling remains challenging. Notably an extensive high...

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Vydáno v:Arch Gynecol Obstet
Hlavní autoři: Grill, Sabine, Ramser, Juliane, Hellebrand, Heide, Pfarr, Nicole, Boxberg, Melanie, Brambs, Christine, Ditsch, Nina, Meindl, Alfons, Groß, Eva, Meitinger, Thomas, Kiechle, Marion, Quante, Anne S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2020
Témata:
Gynecologic Oncology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8087555/
https://ncbi.nlm.nih.gov/pubmed/33245408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00404-020-05883-x
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