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Synthesis, anti-cancer screening and tyrosyl-DNA phosphodiesterase 1 (Tdp1) inhibition activity of novel piperidinyl sulfamides
Novel piperidinyl-based sulfamide derivatives were designed and synthesized through various synthetic routes. Anticancer activities of these sulfamides were evaluated by phenotypic screening on National Cancer Institute’s 60 human tumor cell lines (NCI-60). Preliminary screening at 10 μM concentrati...
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| Publicado en: | Eur J Pharm Sci |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8087116/ https://ncbi.nlm.nih.gov/pubmed/29037996 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejps.2017.10.017 |
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