Combined Inhibition of Gα(q) and MEK Enhances Therapeutic Efficacy in Uveal Melanoma.

PURPOSE: All uveal melanoma and a fraction of other melanoma subtypes are driven by activation of the Gα(q) pathway. Targeting these melanomas has proven difficult despite advances in the molecular understanding of key driver signaling pathways in the disease pathogenesis. Inhibitors of Gα(q) have s...

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Опубликовано в: :Clin Cancer Res
Главные авторы: Hitchman, Tyler D., Bayshtok, Gabriella, Ceraudo, Emilie, Moore, Amanda R., Lee, Cindy, Jia, Ruobing, Wang, Naitao, Pachai, Mohini R., Shoushtari, Alexander N., Francis, Jasmine H., Guan, Youxin, Chen, Juliet, Chang, Matthew T., Taylor, Barry S., Sakmar, Thomas P., Huber, Thomas, Chi, Ping, Chen, Yu
Формат: Artigo
Язык:Inglês
Опубликовано: 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8086191/
https://ncbi.nlm.nih.gov/pubmed/33229459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-2860
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