Combined Inhibition of Gα(q) and MEK Enhances Therapeutic Efficacy in Uveal Melanoma.

PURPOSE: All uveal melanoma and a fraction of other melanoma subtypes are driven by activation of the Gα(q) pathway. Targeting these melanomas has proven difficult despite advances in the molecular understanding of key driver signaling pathways in the disease pathogenesis. Inhibitors of Gα(q) have s...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Clin Cancer Res
Hlavní autoři: Hitchman, Tyler D., Bayshtok, Gabriella, Ceraudo, Emilie, Moore, Amanda R., Lee, Cindy, Jia, Ruobing, Wang, Naitao, Pachai, Mohini R., Shoushtari, Alexander N., Francis, Jasmine H., Guan, Youxin, Chen, Juliet, Chang, Matthew T., Taylor, Barry S., Sakmar, Thomas P., Huber, Thomas, Chi, Ping, Chen, Yu
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8086191/
https://ncbi.nlm.nih.gov/pubmed/33229459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-2860
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky