Combined Inhibition of Gα(q) and MEK Enhances Therapeutic Efficacy in Uveal Melanoma.

PURPOSE: All uveal melanoma and a fraction of other melanoma subtypes are driven by activation of the Gα(q) pathway. Targeting these melanomas has proven difficult despite advances in the molecular understanding of key driver signaling pathways in the disease pathogenesis. Inhibitors of Gα(q) have s...

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Publicado en:Clin Cancer Res
Main Authors: Hitchman, Tyler D., Bayshtok, Gabriella, Ceraudo, Emilie, Moore, Amanda R., Lee, Cindy, Jia, Ruobing, Wang, Naitao, Pachai, Mohini R., Shoushtari, Alexander N., Francis, Jasmine H., Guan, Youxin, Chen, Juliet, Chang, Matthew T., Taylor, Barry S., Sakmar, Thomas P., Huber, Thomas, Chi, Ping, Chen, Yu
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8086191/
https://ncbi.nlm.nih.gov/pubmed/33229459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-2860
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