Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma

Uveal melanomas are molecularly distinct from cutaneous melanomas and lack mutations in BRAF, NRAS, KIT, and NF1. Instead, they are characterized by activating mutations in GNAQ and GNA11, two highly homologous α subunits of G(αq/11) heterotrimeric G proteins, and in PLCB4 (phospholipase C β4), the...

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Bibliographic Details
Published in:Nat Genet
Main Authors: Moore, Amanda R, Ceraudo, Emilie, Sher, Jessica J, Guan, Youxin, Shoushtari, Alexander N, Chang, Matthew T, Zhang, Jenny Q, Walczak, Edward G, Kazmi, Manija A, Taylor, Barry S, Huber, Thomas, Chi, Ping, Sakmar, Thomas P, Chen, Yu
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5032652/
https://ncbi.nlm.nih.gov/pubmed/27089179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3549
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