Involvement of mutant and wild-type CYSLTR2 in the development and progression of uveal nevi and melanoma

BACKGROUND: Activating Gα(q) signalling mutations are considered an early event in the development of uveal melanoma. Whereas most tumours harbour a mutation in GNAQ or GNA11, CYSLTR2 (encoding G-protein coupled receptor CysLT(2)R) forms a rare alternative. The role of wild-type CysLT(2)R in uveal m...

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Publicado en:BMC Cancer
Main Authors: Nell, Rogier J., Menger, Nino V., Versluis, Mieke, Luyten, Gregorius P. M., Verdijk, Robert M., Madigan, Michele C., Jager, Martine J., van der Velden, Pieter A.
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2021
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7885466/
https://ncbi.nlm.nih.gov/pubmed/33588787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-021-07865-x
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