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MARS: leveraging allelic heterogeneity to increase power of association testing

In standard genome-wide association studies (GWAS), the standard association test is underpowered to detect associations between loci with multiple causal variants with small effect sizes. We propose a statistical method, Model-based Association test Reflecting causal Status (MARS), that finds assoc...

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Publicat a:Genome Biol
Autors principals: Hormozdiari, Farhad, Jung, Junghyun, Eskin, Eleazar, J. Joo, Jong Wha
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8086090/
https://ncbi.nlm.nih.gov/pubmed/33931127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-021-02353-8
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