NMD inhibition by 5-azacytidine augments presentation of immunogenic frameshift-derived neoepitopes

Frameshifted protein sequences elicit tumor-specific T cell-mediated immune responses in microsatellite-unstable (MSI) cancers if presented by HLA class I molecules. However, their expression and presentation are limited by nonsense-mediated RNA decay (NMD). We employed an unbiased immunopeptidomics...

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Опубликовано в: :iScience
Главные авторы: Becker, Jonas P., Helm, Dominic, Rettel, Mandy, Stein, Frank, Hernandez-Sanchez, Alejandro, Urban, Katharina, Gebert, Johannes, Kloor, Matthias, Neu-Yilik, Gabriele, von Knebel Doeberitz, Magnus, Hentze, Matthias W., Kulozik, Andreas E.
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier 2021
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8082087/
https://ncbi.nlm.nih.gov/pubmed/33981976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102389
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