STING Activated Tumor-Intrinsic Type I Interferon Signaling Promotes CXCR3 Dependent Antitumor Immunity in Pancreatic Cancer

BACKGROUND & AIMS: Pancreatic ductal adenocarcinoma (PDA) is a lethal chemoresistant cancer that exhibits early metastatic spread. The highly immunosuppressive PDA tumor microenvironment renders patients resistant to emerging immune-targeted therapies. Building from our prior work, we evaluated...

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Publicado en:Cell Mol Gastroenterol Hepatol
Autores principales: Vonderhaar, Emily P., Barnekow, Nicholas S., McAllister, Donna, McOlash, Laura, Eid, Mahmoud Abu, Riese, Matthew J., Tarakanova, Vera L., Johnson, Bryon D., Dwinell, Michael B.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2021
Materias:
Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8081932/
https://ncbi.nlm.nih.gov/pubmed/33548597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2021.01.018
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