2543 High concentrations of CXCL12 decrease pancreatic adenocarcinoma growth

OBJECTIVES/SPECIFIC AIMS: We hypothesized that CXCL12, as a biased dimer variant or secreted at dimer-dominant concentrations, would influence PDAC growth and progression. METHODS/STUDY POPULATION: PDAC cells were genetically manipulated to express dimer-promoting levels of CXCL12. These cells were...

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Detalhes bibliográficos
Publicado no:J Clin Transl Sci
Main Authors: Vonderhaar, Emily, Dwinell, Michael, Roy, Ishan R., McAllister, Donna M., Dwinell, Michael B.
Formato: Artigo
Idioma:Inglês
Publicado em: Cambridge University Press 2018
Assuntos:
Basic/Translational Science/Team Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6798694/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/cts.2018.79
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