Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression

Metabolic heterogeneity within the tumor microenvironment promotes cancer cell growth and immune suppression. We determined the impact of mitochondria-targeted complex I inhibitors (Mito-CI) in melanoma. Mito-CI decreased mitochondria complex I oxygen consumption, Akt-FOXO signaling, blocked cell cy...

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Publicat a:iScience
Autors principals: AbuEid, Mahmoud, McAllister, Donna M., McOlash, Laura, Harwig, Megan Cleland, Cheng, Gang, Drouillard, Donovan, Boyle, Kathleen A., Hardy, Micael, Zielonka, Jacek, Johnson, Bryon D., Hill, R. Blake, Kalyanaraman, Balaraman, Dwinell, Michael B.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8220235/
https://ncbi.nlm.nih.gov/pubmed/34189432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102653
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