Structure, interdomain dynamics, and pH-dependent autoactivation of pro-rhodesain, the main lysosomal cysteine protease from African trypanosomes

Rhodesain is the lysosomal cathepsin L-like cysteine protease of Trypanosoma brucei rhodesiense, the causative agent of Human African Trypanosomiasis. The enzyme is essential for the proliferation and pathogenicity of the parasite as well as its ability to overcome the blood–brain barrier of the hos...

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Vydáno v:J Biol Chem
Hlavní autoři: Johé, Patrick, Jaenicke, Elmar, Neuweiler, Hannes, Schirmeister, Tanja, Kersten, Christian, Hellmich, Ute A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2021
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8080524/
https://ncbi.nlm.nih.gov/pubmed/33745969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100565
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