Naphthoquinones as Covalent Reversible Inhibitors of Cysteine Proteases—Studies on Inhibition Mechanism and Kinetics

The facile synthesis and detailed investigation of a class of highly potent protease inhibitors based on 1,4-naphthoquinones with a dipeptidic recognition motif (HN-l-Phe-l-Leu-OR) in the 2-position and an electron-withdrawing group (EWG) in the 3-position is presented. One of the compound represent...

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Veröffentlicht in:Molecules
Hauptverfasser: Klein, Philipp, Barthels, Fabian, Johe, Patrick, Wagner, Annika, Tenzer, Stefan, Distler, Ute, Le, Thien Anh, Schmid, Paul, Engel, Volker, Engels, Bernd, Hellmich, Ute A., Opatz, Till, Schirmeister, Tanja
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7248907/
https://ncbi.nlm.nih.gov/pubmed/32354191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25092064
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