Potent and Selective Inhibition of Cysteine Proteases from Plasmodium falciparum and Trypanosoma brucei

Treating tropical diseases: Structure‐based design afforded highly active triazine nitrile inhibitors of the protozoan cysteine proteases falcipain‐2 and rhodesain. Optimization of the occupancy of the S1, S2, and S3 pockets of these enzymes yielded inhibitory constants in the low nanomolar activity...

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Detalhes bibliográficos
Publicado no:ChemMedChem
Principais autores: Ehmke, Veronika, Heindl, Cornelia, Rottmann, Matthias, Freymond, Céline, Schweizer, W. Bernd, Brun, Reto, Stich, August, Schirmeister, Tanja, Diederich, François
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY‐VCH Verlag 2011
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7162187/
https://ncbi.nlm.nih.gov/pubmed/21275051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201000449
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