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Potent and Selective Inhibition of Cysteine Proteases from Plasmodium falciparum and Trypanosoma brucei
Treating tropical diseases: Structure‐based design afforded highly active triazine nitrile inhibitors of the protozoan cysteine proteases falcipain‐2 and rhodesain. Optimization of the occupancy of the S1, S2, and S3 pockets of these enzymes yielded inhibitory constants in the low nanomolar activity...
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| Publicado no: | ChemMedChem |
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| Principais autores: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
WILEY‐VCH Verlag
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7162187/ https://ncbi.nlm.nih.gov/pubmed/21275051 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201000449 |
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