Potent and Selective Inhibition of Cysteine Proteases from Plasmodium falciparum and Trypanosoma brucei

Treating tropical diseases: Structure‐based design afforded highly active triazine nitrile inhibitors of the protozoan cysteine proteases falcipain‐2 and rhodesain. Optimization of the occupancy of the S1, S2, and S3 pockets of these enzymes yielded inhibitory constants in the low nanomolar activity...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:ChemMedChem
Main Authors: Ehmke, Veronika, Heindl, Cornelia, Rottmann, Matthias, Freymond, Céline, Schweizer, W. Bernd, Brun, Reto, Stich, August, Schirmeister, Tanja, Diederich, François
Format: Artigo
Sprog:Inglês
Udgivet: WILEY‐VCH Verlag 2011
Fag:
Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7162187/
https://ncbi.nlm.nih.gov/pubmed/21275051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201000449
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker