Potent and Selective Inhibition of Cysteine Proteases from Plasmodium falciparum and Trypanosoma brucei

Treating tropical diseases: Structure‐based design afforded highly active triazine nitrile inhibitors of the protozoan cysteine proteases falcipain‐2 and rhodesain. Optimization of the occupancy of the S1, S2, and S3 pockets of these enzymes yielded inhibitory constants in the low nanomolar activity...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:ChemMedChem
Egile Nagusiak: Ehmke, Veronika, Heindl, Cornelia, Rottmann, Matthias, Freymond, Céline, Schweizer, W. Bernd, Brun, Reto, Stich, August, Schirmeister, Tanja, Diederich, François
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: WILEY‐VCH Verlag 2011
Gaiak:
Communications
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7162187/
https://ncbi.nlm.nih.gov/pubmed/21275051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201000449
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