Potent and Selective Inhibition of Cysteine Proteases from Plasmodium falciparum and Trypanosoma brucei

Treating tropical diseases: Structure‐based design afforded highly active triazine nitrile inhibitors of the protozoan cysteine proteases falcipain‐2 and rhodesain. Optimization of the occupancy of the S1, S2, and S3 pockets of these enzymes yielded inhibitory constants in the low nanomolar activity...

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Publicat a:ChemMedChem
Autors principals: Ehmke, Veronika, Heindl, Cornelia, Rottmann, Matthias, Freymond, Céline, Schweizer, W. Bernd, Brun, Reto, Stich, August, Schirmeister, Tanja, Diederich, François
Format: Artigo
Idioma:Inglês
Publicat: WILEY‐VCH Verlag 2011
Matèries:
Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7162187/
https://ncbi.nlm.nih.gov/pubmed/21275051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201000449
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