Benzimidazole inhibitors of the major cysteine protease of Trypanosoma brucei

AIM: Limitations in available therapies for trypanosomiases indicate the need for improved medicines. Cysteine proteases cruzain and rhodesain are validated targets for treatment of Chagas disease and human African trypanosomiasis. Previous studies reported a benzimidazole series as potent cruzain i...

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Enregistré dans:
Détails bibliographiques
Publié dans:Future Med Chem
Auteurs principaux: Pereira, Glaécia AN, Santos, Lucianna H, Wang, Steven C, Martins, Luan C, Villela, Filipe S, Liao, Weiting, Dessoy, Marco A, Dias, Luiz C, Andricopulo, Adriano D, Costa, Mariana AF, Nagem, Ronaldo AP, Caffrey, Conor R, Liedl, Klaus R, Caffarena, Ernesto R, Ferreira, Rafaela S
Format: Artigo
Langue:Inglês
Publié: Newlands Press Ltd 2019
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6722484/
https://ncbi.nlm.nih.gov/pubmed/31469332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fmc-2018-0523
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