Astrocyte-specific expression of interleukin 23 leads to an aggravated phenotype and enhanced inflammatory response with B cell accumulation in the EAE model

BACKGROUND: Interleukin 23 is a critical cytokine in the pathogenesis of multiple sclerosis. But the local impact of interleukin 23 on the course of neuroinflammation is still not well defined. To further characterize the effect of interleukin 23 on CNS inflammation, we recently described a transgen...

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Détails bibliographiques
Publié dans:J Neuroinflammation
Auteurs principaux: Nitsch, Louisa, Petzinna, Simon, Zimmermann, Julian, Schneider, Linda, Krauthausen, Marius, Heneka, Michael T., Getts, Daniel R., Becker, Albert, Müller, Marcus
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2021
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8080359/
https://ncbi.nlm.nih.gov/pubmed/33906683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-021-02140-z
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