The Nek2 centrosome-mitotic kinase contributes to the mesenchymal state, cell invasion, and migration of triple-negative breast cancer cells

Nek2 (NIMA‐related kinase 2) is a serine/threonine-protein kinase that localizes to centrosomes and kinetochores, controlling centrosome separation, chromosome attachments to kinetochores, and the spindle assembly checkpoint. These processes prevent centrosome amplification (CA), mitotic dysfunction...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Rivera-Rivera, Yainyrette, Marina, Mihaela, Jusino, Shirley, Lee, Miyoung, Velázquez, Jaleisha Vélez, Chardón-Colón, Camille, Vargas, Geraldine, Padmanabhan, Jaya, Chellappan, Srikumar P., Saavedra, Harold I.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8079711/
https://ncbi.nlm.nih.gov/pubmed/33907253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-88512-0
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