Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades most innate immune responses but may still be vulnerable to some. Here, we systematically analyze the impact of SARS-CoV-2 proteins on interferon (IFN) responses and autophagy. We show that SARS-CoV-2 proteins synergize to counterac...

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發表在:Cell Rep
Main Authors: Hayn, Manuel, Hirschenberger, Maximilian, Koepke, Lennart, Nchioua, Rayhane, Straub, Jan Hendrik, Klute, Susanne, Hunszinger, Victoria, Zech, Fabian, Prelli Bozzo, Caterina, Aftab, Wasim, Christensen, Maria Hønholt, Conzelmann, Carina, Müller, Janis Alexander, Srinivasachar Badarinarayan, Smitha, Stürzel, Christina Martina, Forne, Ignasi, Stenger, Steffen, Conzelmann, Karl-Klaus, Münch, Jan, Schmidt, Florian Ingo, Sauter, Daniel, Imhof, Axel, Kirchhoff, Frank, Sparrer, Konstantin Maria Johannes
格式: Artigo
語言:Inglês
出版: Cell Press 2021
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8078906/
https://ncbi.nlm.nih.gov/pubmed/33974846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.109126
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