IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro

Interferon-induced transmembrane proteins (IFITMs 1, 2 and 3) can restrict viral pathogens, but pro- and anti-viral activities have been reported for coronaviruses. Here, we show that artificial overexpression of IFITMs blocks SARS-CoV-2 infection. However, endogenous IFITM expression supports effic...

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Vydáno v:Nat Commun
Hlavní autoři: Prelli Bozzo, Caterina, Nchioua, Rayhane, Volcic, Meta, Koepke, Lennart, Krüger, Jana, Schütz, Desiree, Heller, Sandra, Stürzel, Christina M., Kmiec, Dorota, Conzelmann, Carina, Müller, Janis, Zech, Fabian, Braun, Elisabeth, Groß, Rüdiger, Wettstein, Lukas, Weil, Tatjana, Weiß, Johanna, Diofano, Federica, Rodríguez Alfonso, Armando A., Wiese, Sebastian, Sauter, Daniel, Münch, Jan, Goffinet, Christine, Catanese, Alberto, Schön, Michael, Boeckers, Tobias M., Stenger, Steffen, Sato, Kei, Just, Steffen, Kleger, Alexander, Sparrer, Konstantin M. J., Kirchhoff, Frank
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8319209/
https://ncbi.nlm.nih.gov/pubmed/34321474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24817-y
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