Comprehensive Analysis of CDR3 Sequences in Gluten-Specific T-Cell Receptors Reveals a Dominant R-Motif and Several New Minor Motifs

Gluten-specific CD4+ T cells are drivers of celiac disease (CeD). Previous studies of gluten-specific T-cell receptor (TCR) repertoires have found public TCRs shared across multiple individuals, biased usage of particular V-genes and conserved CDR3 motifs. The CDR3 motifs within the gluten-specific...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Dahal-Koirala, Shiva, Risnes, Louise Fremgaard, Neumann, Ralf Stefan, Christophersen, Asbjørn, Lundin, Knut E. A., Sandve, Geir Kjetil, Qiao, Shuo-Wang, Sollid, Ludvig M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8076556/
https://ncbi.nlm.nih.gov/pubmed/33927715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.639672
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