Disease-driving CD4(+) T cell clonotypes persist for decades in celiac disease

Little is known about the repertoire dynamics and persistence of pathogenic T cells in HLA-associated disorders. In celiac disease, a disorder with a strong association with certain HLA-DQ allotypes, presumed pathogenic T cells can be visualized and isolated with HLA-DQ:gluten tetramers, thereby ena...

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Udgivet i:J Clin Invest
Main Authors: Risnes, Louise F., Christophersen, Asbjørn, Dahal-Koirala, Shiva, Neumann, Ralf S., Sandve, Geir K., Sarna, Vikas K., Lundin, Knut E.A., Qiao, Shuo-Wang, Sollid, Ludvig M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5983310/
https://ncbi.nlm.nih.gov/pubmed/29757191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI98819
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