Comparative analysis of genome-wide DNA methylation identifies patterns that associate with conserved transcriptional programs in osteosarcoma.

Osteosarcoma is an aggressive tumor of the bone that primarily affects young adults and adolescents. Osteosarcoma is characterized by genomic chaos and heterogeneity. While inactivation of tumor protein p53 (TP53) is nearly universal other high frequency mutations or structural variations have not b...

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Detalhes bibliográficos
Publicado no:Bone
Main Authors: Mills, Lauren J., Scott, Milcah C., Shah, Pankti, Cunanan, Anne R., Deshpande, Archana, Auch, Benjamin, Curtin, Bridget, Beckman, Kenneth B., Spector, Logan G., Sarver, Aaron L., Subramanian, Subbaya, Richmond, Todd A., Modiano, Jaime F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2022
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8076342/
https://ncbi.nlm.nih.gov/pubmed/33127576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2020.115716
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