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Comparative analysis of genome-wide DNA methylation identifies patterns that associate with conserved transcriptional programs in osteosarcoma.

Osteosarcoma is an aggressive tumor of the bone that primarily affects young adults and adolescents. Osteosarcoma is characterized by genomic chaos and heterogeneity. While inactivation of tumor protein p53 (TP53) is nearly universal other high frequency mutations or structural variations have not b...

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Détails bibliographiques
Publié dans:Bone
Auteurs principaux: Mills, Lauren J., Scott, Milcah C., Shah, Pankti, Cunanan, Anne R., Deshpande, Archana, Auch, Benjamin, Curtin, Bridget, Beckman, Kenneth B., Spector, Logan G., Sarver, Aaron L., Subramanian, Subbaya, Richmond, Todd A., Modiano, Jaime F.
Format: Artigo
Langue:Inglês
Publié: 2022
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8076342/
https://ncbi.nlm.nih.gov/pubmed/33127576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2020.115716
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