Aberrant Retinoblastoma (RB)-E2F Transcriptional Regulation Defines Molecular Phenotypes of Osteosarcoma

We previously identified two distinct molecular subtypes of osteosarcoma through gene expression profiling. These subtypes are associated with distinct tumor behavior and clinical outcomes. Here, we describe mechanisms that give rise to these molecular subtypes. Using bioinformatic analyses, we iden...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Scott, Milcah C., Sarver, Aaron L., Tomiyasu, Hirotaka, Cornax, Ingrid, Van Etten, Jamie, Varshney, Jyotika, O'Sullivan, M. Gerard, Subramanian, Subbaya, Modiano, Jaime F.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653667/
https://ncbi.nlm.nih.gov/pubmed/26378234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.679696
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