Targeting IRAK4 disrupts inflammatory pathways and delays tumor development in chronic lymphocytic leukemia

Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a critical role in Toll-like receptor (TLR) signal transduction and innate immune responses. Recruitment and subsequent activation of IRAK4 upon TLR stimulation is mediated by the myeloid differentiation primary response 88 (MYD88) adaptor pro...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Giménez, Neus, Schulz, Ralph, Higashi, Morihiro, Aymerich, Marta, Villamor, Neus, Delgado, Julio, Juan, Manel, López-Guerra, Mònica, Campo, Elias, Rosich, Laia, Seiffert, Martina, Colomer, Dolors
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8075947/
https://ncbi.nlm.nih.gov/pubmed/31197259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-019-0507-8
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