Epithelium-autonomous NAIP/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice

The gut epithelium is a critical protective barrier. Its NAIP/NLRC4 inflammasome senses infection by Gram-negative bacteria, including Salmonella Typhimurium (S.Tm) and promotes expulsion of infected enterocytes. During the first ~12–24 h, this reduces mucosal S.Tm loads at the price of moderate ent...

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Bibliographic Details
Published in:Mucosal Immunol
Main Authors: Fattinger, Stefan A., Geiser, Petra, Samperio Ventayol, Pilar, Di Martino, Maria Letizia, Furter, Markus, Felmy, Boas, Bakkeren, Erik, Hausmann, Annika, Barthel-Scherrer, Manja, Gül, Ersin, Hardt, Wolf-Dietrich, Sellin, Mikael E.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group US 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8075861/
https://ncbi.nlm.nih.gov/pubmed/33731826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41385-021-00381-y
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