Aneuploid abortion correlates positively with MAD1 overexpression and miR-125b down-regulation

BACKGROUND: Aneuploidy is the most frequent cause of early-embryo abortion. Any defect in chromosome segregation would fail to satisfy the spindle assembly checkpoint (SAC) during mitosis, halting metaphase and causing aneuploidy. The mitotic checkpoint complex (MCC), comprising MAD1, MAD2, Cdc20, B...

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Udgivet i:Mol Cytogenet
Main Authors: Zhao, Juan, Li, Hui, Chen, Guangxin, Du, Lijun, Xu, Peiyan, Zhang, Xiaoli, Xie, Min, Cao, Tiansheng, Li, Haibo
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8074413/
https://ncbi.nlm.nih.gov/pubmed/33902659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13039-021-00538-1
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